Loss of introns along the evolutionary diversification pathway of snake venom disintegrins evidenced by sequence analysis of genomic DNA from Macrovipera lebetina transmediterranea and Echis ocellatus.
Identifieur interne : 000036 ( Main/Exploration ); précédent : 000035; suivant : 000037Loss of introns along the evolutionary diversification pathway of snake venom disintegrins evidenced by sequence analysis of genomic DNA from Macrovipera lebetina transmediterranea and Echis ocellatus.
Auteurs : Amine Bazaa [Tunisie] ; Paula Juárez ; Néziha Marrakchi ; Zakaria Bel Lasfer ; Mohamed El Ayeb ; Robert A. Harrison ; Juan J. Calvete ; Libia SanzSource :
- Journal of molecular evolution [ 0022-2844 ] ; 2007.
Descripteurs français
- KwdFr :
- ADN (composition chimique), ADN (génétique), ADN (isolement et purification), ADN complémentaire (MeSH), Alignement de séquences (MeSH), Amorces ADN (MeSH), Animaux (MeSH), Données de séquences moléculaires (MeSH), Délétion de séquence (MeSH), Désintégrines (génétique), Introns (MeSH), Phylogenèse (MeSH), Similitude de séquences d'acides aminés (MeSH), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH), Variation génétique (MeSH), Venins de vipère (composition chimique), Venins de vipère (génétique), Viperidae (classification), Viperidae (génétique).
- MESH :
- composition chimique : ADN, Venins de vipère, Viperidae.
- génétique : ADN, Désintégrines, Venins de vipère, Viperidae.
- isolement et purification : ADN.
- ADN complémentaire, Alignement de séquences, Amorces ADN, Animaux, Données de séquences moléculaires, Délétion de séquence, Introns, Phylogenèse, Similitude de séquences d'acides aminés, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Base Sequence (MeSH), DNA (chemistry), DNA (genetics), DNA (isolation & purification), DNA Primers (MeSH), DNA, Complementary (MeSH), Disintegrins (genetics), Genetic Variation (MeSH), Introns (MeSH), Molecular Sequence Data (MeSH), Phylogeny (MeSH), Sequence Alignment (MeSH), Sequence Deletion (MeSH), Sequence Homology, Amino Acid (MeSH), Viper Venoms (chemistry), Viper Venoms (genetics), Viperidae (classification), Viperidae (genetics).
- MESH :
- chemical , chemistry : DNA, Viper Venoms.
- chemical , genetics : DNA, Disintegrins, Viper Venoms.
- chemical , isolation & purification : DNA.
- classification : Viperidae.
- genetics : Viperidae.
- Amino Acid Sequence, Animals, Base Sequence, DNA Primers, DNA, Complementary, Genetic Variation, Introns, Molecular Sequence Data, Phylogeny, Sequence Alignment, Sequence Deletion, Sequence Homology, Amino Acid.
Abstract
Analysis of cDNAs from Macrovipera lebetina transmediterranea (Mlt) and Echis ocellatus (Eo) venom gland libraries encoding disintegrins argued strongly for a common ancestry of the messengers of short disintegrins and those for precursors of dimeric disintegrin chains. We now report the sequence analysis of disintegrin-coding genes from these two vipers. Genomic DNAs for dimeric disintegrin subunits Ml_G1 and Ml_G2 (Mlt) and Eo_D3 (Eo) contain single 1-kb introns exhibiting the 5'-GTAAG (donor)/3'-AG (acceptor) consensus intron splicing signature. On the other hand, the short RTS-disintegrins Ml_G3 (Mlt) and Eo_RTS (Eo) and the short RGD-disintegrin ocellatusin (Eo) are transcribed from intronless genomic DNA sequences, indicating that the evolutionary pathway leading to the emergence of short disintegrins involved the removal of all intronic sequences. The insertion position of the intron within Ml_G1, Ml_G2, and Eo_D3 is conserved in the genes for vertebrate ADAM (A disintegrin and metalloproteinase) protein disintegrin-like domains and within the gene for the medium-size snake disintegrins halystatins 2 and 3. However, a comparative analysis of currently available disintegrin(-like) genes outlines the view that a minimization of both the gene organization and the protein structure underlies the evolution of the snake venom disintegrin family.
DOI: 10.1007/s00239-006-0161-4
PubMed: 17177090
Affiliations:
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Le document en format XML
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<author><name sortKey="El Ayeb, Mohamed" sort="El Ayeb, Mohamed" uniqKey="El Ayeb M" first="Mohamed" last="El Ayeb">Mohamed El Ayeb</name>
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<author><name sortKey="Harrison, Robert A" sort="Harrison, Robert A" uniqKey="Harrison R" first="Robert A" last="Harrison">Robert A. Harrison</name>
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<author><name sortKey="Calvete, Juan J" sort="Calvete, Juan J" uniqKey="Calvete J" first="Juan J" last="Calvete">Juan J. Calvete</name>
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<author><name sortKey="El Ayeb, Mohamed" sort="El Ayeb, Mohamed" uniqKey="El Ayeb M" first="Mohamed" last="El Ayeb">Mohamed El Ayeb</name>
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<author><name sortKey="Sanz, Libia" sort="Sanz, Libia" uniqKey="Sanz L" first="Libia" last="Sanz">Libia Sanz</name>
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<series><title level="j">Journal of molecular evolution</title>
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<term>Animals (MeSH)</term>
<term>Base Sequence (MeSH)</term>
<term>DNA (chemistry)</term>
<term>DNA (genetics)</term>
<term>DNA (isolation & purification)</term>
<term>DNA Primers (MeSH)</term>
<term>DNA, Complementary (MeSH)</term>
<term>Disintegrins (genetics)</term>
<term>Genetic Variation (MeSH)</term>
<term>Introns (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>Sequence Alignment (MeSH)</term>
<term>Sequence Deletion (MeSH)</term>
<term>Sequence Homology, Amino Acid (MeSH)</term>
<term>Viper Venoms (chemistry)</term>
<term>Viper Venoms (genetics)</term>
<term>Viperidae (classification)</term>
<term>Viperidae (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN (composition chimique)</term>
<term>ADN (génétique)</term>
<term>ADN (isolement et purification)</term>
<term>ADN complémentaire (MeSH)</term>
<term>Alignement de séquences (MeSH)</term>
<term>Amorces ADN (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Délétion de séquence (MeSH)</term>
<term>Désintégrines (génétique)</term>
<term>Introns (MeSH)</term>
<term>Phylogenèse (MeSH)</term>
<term>Similitude de séquences d'acides aminés (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Séquence nucléotidique (MeSH)</term>
<term>Variation génétique (MeSH)</term>
<term>Venins de vipère (composition chimique)</term>
<term>Venins de vipère (génétique)</term>
<term>Viperidae (classification)</term>
<term>Viperidae (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term>
<term>Viper Venoms</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA</term>
<term>Disintegrins</term>
<term>Viper Venoms</term>
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<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Viperidae</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>ADN</term>
<term>Venins de vipère</term>
<term>Viperidae</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Viperidae</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN</term>
<term>Désintégrines</term>
<term>Venins de vipère</term>
<term>Viperidae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ADN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>DNA Primers</term>
<term>DNA, Complementary</term>
<term>Genetic Variation</term>
<term>Introns</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Sequence Alignment</term>
<term>Sequence Deletion</term>
<term>Sequence Homology, Amino Acid</term>
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<term>Alignement de séquences</term>
<term>Amorces ADN</term>
<term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Délétion de séquence</term>
<term>Introns</term>
<term>Phylogenèse</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Variation génétique</term>
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<front><div type="abstract" xml:lang="en">Analysis of cDNAs from Macrovipera lebetina transmediterranea (Mlt) and Echis ocellatus (Eo) venom gland libraries encoding disintegrins argued strongly for a common ancestry of the messengers of short disintegrins and those for precursors of dimeric disintegrin chains. We now report the sequence analysis of disintegrin-coding genes from these two vipers. Genomic DNAs for dimeric disintegrin subunits Ml_G1 and Ml_G2 (Mlt) and Eo_D3 (Eo) contain single 1-kb introns exhibiting the 5'-GTAAG (donor)/3'-AG (acceptor) consensus intron splicing signature. On the other hand, the short RTS-disintegrins Ml_G3 (Mlt) and Eo_RTS (Eo) and the short RGD-disintegrin ocellatusin (Eo) are transcribed from intronless genomic DNA sequences, indicating that the evolutionary pathway leading to the emergence of short disintegrins involved the removal of all intronic sequences. The insertion position of the intron within Ml_G1, Ml_G2, and Eo_D3 is conserved in the genes for vertebrate ADAM (A disintegrin and metalloproteinase) protein disintegrin-like domains and within the gene for the medium-size snake disintegrins halystatins 2 and 3. However, a comparative analysis of currently available disintegrin(-like) genes outlines the view that a minimization of both the gene organization and the protein structure underlies the evolution of the snake venom disintegrin family.</div>
</front>
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<affiliations><list><country><li>Tunisie</li>
</country>
</list>
<tree><noCountry><name sortKey="Bel Lasfer, Zakaria" sort="Bel Lasfer, Zakaria" uniqKey="Bel Lasfer Z" first="Zakaria" last="Bel Lasfer">Zakaria Bel Lasfer</name>
<name sortKey="Calvete, Juan J" sort="Calvete, Juan J" uniqKey="Calvete J" first="Juan J" last="Calvete">Juan J. Calvete</name>
<name sortKey="El Ayeb, Mohamed" sort="El Ayeb, Mohamed" uniqKey="El Ayeb M" first="Mohamed" last="El Ayeb">Mohamed El Ayeb</name>
<name sortKey="Harrison, Robert A" sort="Harrison, Robert A" uniqKey="Harrison R" first="Robert A" last="Harrison">Robert A. Harrison</name>
<name sortKey="Juarez, Paula" sort="Juarez, Paula" uniqKey="Juarez P" first="Paula" last="Juárez">Paula Juárez</name>
<name sortKey="Marrakchi, Neziha" sort="Marrakchi, Neziha" uniqKey="Marrakchi N" first="Néziha" last="Marrakchi">Néziha Marrakchi</name>
<name sortKey="Sanz, Libia" sort="Sanz, Libia" uniqKey="Sanz L" first="Libia" last="Sanz">Libia Sanz</name>
</noCountry>
<country name="Tunisie"><noRegion><name sortKey="Bazaa, Amine" sort="Bazaa, Amine" uniqKey="Bazaa A" first="Amine" last="Bazaa">Amine Bazaa</name>
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